Across TCGA pan-cancer cohorts, IGHV3-64 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated IGHV3-64 data layer compared with 22 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher IGHV3-64 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IGHV3-64 expression acts as an unfavorable survival marker.

SKCM and LUSC are the cancer types where IGHV3-64 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.102	0.344	<.001	20	view →
LUSC	OS	Median	All	0.112	0.762	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: IGHV3-64 tumor-vs-normal RNA expression · all IGHV3-64 data types