Across TCGA pan-cancer cohorts, IGHV3-64 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IGHV3-64 data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IGHV3-64 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated IGHV3-64 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LUAD, GBM, and HNSC are the cancer types where IGHV3-64 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.763	1.000	.012	17	view →
GBM	OS	Median	All	0.265	0.531	.004	9	view →
HNSC	OS	Median	II,III,IV	0.950	1.000	.016	6	view →
LSCC	DFS	Median	All	0.909	0.967	.025	4	view →
CCRCC	OS	Median	All	1.000	0.897	.015	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: IGHV3-64 tumor-vs-normal RNA expression · all IGHV3-64 data types