Across TCGA pan-cancer cohorts, IGHV3-53 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated IGHV3-53 data layer compared with 28 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IGHV3-53 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3-53 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LUAD and LSCC are the cancer types where IGHV3-53 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.963	0.582	.009	12	view →
LSCC	OS	Quartile	II,III,IV	0.589	0.917	.026	1	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: IGHV3-53 tumor-vs-normal RNA expression · all IGHV3-53 data types