Across TCGA patient cohorts, IGHV3-53 mutation is significantly associated with the RNA expression of many other genes, with 66 significant associations in total. COAD shows the largest number of these associations.

The most reproducible IGHV3-53-associated genes across cancer lineages are PGM5P3-AS1, RNA5SP335, and ARF4P3. Each is linked with IGHV3-53 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3-53-to-partner and partner-to-IGHV3-53 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-53→partner) and Y-score (partner→IGHV3-53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PGM5P3-AS1 →	+0.262	+3.877	<.001	.004	3	1
COAD	RNA5SP335 →	+0.841	+5.435	.001	.005	3	1
COAD	ARF4P3 →	+0.434	+5.435	<.001	.005	3	1
COAD	GTF3C6P1 →	+0.270	+5.017	<.001	.009	3	1
COAD	RPL26P34 →	+0.472	+5.017	<.001	.009	3	1
COAD	RPL32P19 →	+0.402	+5.017	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

Exploration

IGHV3-53 survival (RNA) · tumor vs normal (RNA) · all IGHV3-53 data types