Across TCGA patient cohorts, IGHV3-49 mutation is significantly associated with the RNA expression of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHV3-49-associated genes across cancer lineages are MIR517B, CKS1BP6, and RNU7-176P. Each is linked with IGHV3-49 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3-49-to-partner and partner-to-IGHV3-49 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-49→partner) and Y-score (partner→IGHV3-49) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR517B →	+0.255	+4.900	<.001	.002	3	2
UCEC	CKS1BP6 →	+0.598	+3.466	.002	.008	3	1
COAD	RNU7-176P →	+0.537	+7.741	<.001	.009	3	1
UCEC	IL21 →	+0.208	+3.348	<.001	.004	3	1
SKCM	RPL7P49 →	+0.089	+3.230	<.001	.003	3	1
SKCM	RN7SL465P →	+0.051	+4.408	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

Exploration

IGHV3-49 survival (RNA) · tumor vs normal (RNA) · all IGHV3-49 data types