Across TCGA pan-cancer cohorts, IGHV3-48 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated IGHV3-48 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IGHV3-48 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated IGHV3-48 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

LUAD, CCRCC, and GBM are the cancer types where IGHV3-48 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	III,IV	0.239	1.000	.010	50	view →
CCRCC	DFS	Tertile	II,III,IV	0.869	0.246	.005	14	view →
GBM	DFS	Median	All	0.360	0.167	.019	5	view →
HNSC	OS	Quartile	III,IV	0.962	0.626	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: IGHV3-48 tumor-vs-normal RNA expression · all IGHV3-48 data types