IGHV3-48

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, IGHV3-48 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHV3-48-associated genes across cancer lineages are RNU6-591P and USP9YP2. Each is linked with IGHV3-48 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3-48-to-partner and partner-to-IGHV3-48 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-48→partner) and Y-score (partner→IGHV3-48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECRNU6-591P →+0.652+8.066<.001.00731
UCECUSP9YP2 →+0.054+8.066<.001.00731
Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

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