IGHV3-43

Across TCGA pan-cancer cohorts, IGHV3-43 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated IGHV3-43 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher IGHV3-43 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3-43 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, HNSC, and UCEC are the cancer types where IGHV3-43 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	1.000	0.840	.013	26	view →
HNSC	DFS	Quartile	III,IV	0.894	0.652	.007	24	view →
UCEC	DFS	Quartile	All	0.689	0.934	.008	16	view →
PDAC	DFS	Quartile	III,IV	0.158	0.759	.006	11	view →
LUAD	DFS	Quartile	All	1.000	0.669	.037	3	view →
LSCC	DFS	Quartile	All	0.869	0.999	.017	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

IGHV3-43–CCRCC (DFS)

Open the CCRCC breakdown →