IGHV3-33

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, IGHV3-33 mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHV3-33-associated genes across cancer lineages are LINC02129, MIR98, and MIR6894. Each is linked with IGHV3-33 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3-33-to-partner and partner-to-IGHV3-33 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-33→partner) and Y-score (partner→IGHV3-33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECLINC02129 →+0.232+3.496<.001.00532
UCECMIR98 →+0.605+3.801<.001.00431
UCECMIR6894 →+1.133+3.496<.001.00531
LUADRNY1P3 →+0.573+7.930<.001.00831
LUADRNU6-916P →+0.288+7.930<.001.00831
LUADRNA5SP408 →+0.308+7.930<.001.00831
Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Exploration