IGHV3-22

Across TCGA pan-cancer cohorts, IGHV3-22 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated IGHV3-22 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-22 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGHV3-22 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and UCEC are the cancer types where IGHV3-22 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.724	0.595	<.001	144	view →
BRCA	OS	Median	All	0.978	0.946	<.001	82	view →
UCEC	OS	Median	III,IV	0.752	0.447	.001	56	view →
UVM	OS	Tertile	III,IV	0.104	0.813	.001	45	view →
KIRP	DFS	Tertile	All	0.539	0.861	.005	31	view →
COAD	OS	Median	II,III,IV	0.835	0.737	.013	27	view →
CHOL	DFS	Quartile	All	0.889	0.303	.005	21	view →
SKCM	DFS	Quartile	All	0.688	0.593	.004	20	view →
LUAD	DFS	Quartile	III,IV	0.723	0.315	.020	18	view →
ACC	OS	Tertile	IV	0.327	0.633	.045	18	view →
THYM	OS	Tertile	II,III,IV	0.952	0.517	.007	11	view →
KIRC	DFS	Median	III,IV	0.796	0.689	.009	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

IGHV3-22–HNSC (OS)

Open the HNSC breakdown →