Across TCGA pan-cancer cohorts, IGHV3-21 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated IGHV3-21 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher IGHV3-21 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHV3-21 expression acts as an unfavorable survival marker.

COAD, LIHC, and SKCM are the cancer types where IGHV3-21 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.028	0.668	<.001	18	view →
LIHC	OS	Median	All	0.255	0.773	.012	9	view →
SKCM	OS	Median	III,IV	0.245	0.721	.018	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: IGHV3-21 tumor-vs-normal RNA expression · all IGHV3-21 data types