Across TCGA patient cohorts, IGHV3-21 mutation is significantly associated with the RNA expression of many other genes, with 216 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGHV3-21-associated genes across cancer lineages are RNU6-497P, EIF3JP1, and RNA5SP412. Each is linked with IGHV3-21 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3-21-to-partner and partner-to-IGHV3-21 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-21→partner) and Y-score (partner→IGHV3-21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-497P →	+0.222	+3.419	<.001	<.001	3	2
UCEC	EIF3JP1 →	+0.460	+4.690	<.001	.003	3	2
UCEC	RNA5SP412 →	+2.102	+4.552	<.001	.005	3	1
COAD	RNU1-132P →	+0.325	+6.917	<.001	<.001	3	1
COAD	RNA5SP442 →	+0.500	+5.893	.005	.002	3	1
COAD	MRPL35P1 →	+0.214	+5.017	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 216 associations by consensus.

Exploration

IGHV3-21 survival (RNA) · tumor vs normal (RNA) · all IGHV3-21 data types