Across TCGA patient cohorts, IGHV2-70D RNA expression is significantly associated with the go_rna of many other GO terms, with 7,037 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGHV2-70D-associated GO terms across cancer lineages are Antibacterial humoral response, Complement activation, classical pathway, and Humoral immune response mediated by circulating immunoglobulin. Each is linked with IGHV2-70D in more than 30 cancer types. Because this analysis shows association rather than direction, both IGHV2-70D-to-partner and partner-to-IGHV2-70D results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV2-70D→partner) and Y-score (partner→IGHV2-70D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	Antibacterial humoral response →	+0.151	+2.378	<.001	<.001	3	31
THCA	Complement activation, classical pathway →	+0.188	+2.195	<.001	<.001	3	31
THCA	Humoral immune response mediated by circulating immunoglobulin →	+0.151	+2.180	<.001	<.001	3	30
CHOL	B cell receptor signaling pathway →	+0.093	+2.230	.003	<.001	2	31
THCA	Complement activation →	+0.145	+2.157	<.001	<.001	3	30
CHOL	Positive regulation of leukocyte proliferation →	+0.054	+2.415	.002	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,037 associations by consensus.

Exploration

IGHV2-70D survival (RNA) · tumor vs normal (RNA) · all IGHV2-70D data types