Across TCGA patient cohorts, IGHV2-70D protein abundance is significantly associated with the RNA expression of many other genes, with 5,258 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHV2-70D-associated genes across cancer lineages are IGHV1-69, IGKV2D-29, and IGHV2-70. Each is linked with IGHV2-70D in more than 4 cancer types. Because this analysis shows association rather than direction, both IGHV2-70D-to-partner and partner-to-IGHV2-70D results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV2-70D→partner) and Y-score (partner→IGHV2-70D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IGHV1-69 →	+2.748	+1.637	.006	.002	3	5
CCRCC	IGKV2D-29 →	+1.549	+1.080	.001	.001	3	3
LSCC	IGHV2-70 →	+1.890	+1.197	<.001	<.001	3	3
LUAD	ESRP1 →	-0.643	-1.040	.001	.007	3	3
OV	NUF2 →	-1.805	-2.599	<.001	.002	3	3
OV	LRR1 →	-1.295	-2.268	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,258 associations by consensus.

Exploration

IGHV2-70D survival (RNA) · tumor vs normal (RNA) · all IGHV2-70D data types