Across TCGA patient cohorts, IGHV2-5 protein abundance is significantly associated with the RNA expression of many other genes, with 11,749 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHV2-5-associated genes across cancer lineages are POU2AF1, IGKV3D-20, and IGLV3-27. Each is linked with IGHV2-5 in more than 6 cancer types. Because this analysis shows association rather than direction, both IGHV2-5-to-partner and partner-to-IGHV2-5 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV2-5→partner) and Y-score (partner→IGHV2-5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	POU2AF1 →	+1.469	+0.575	<.001	<.001	3	7
LSCC	IGKV3D-20 →	+2.093	+0.468	<.001	<.001	3	7
HNSC	IGLV3-27 →	+2.366	+0.786	<.001	<.001	3	7
LSCC	IGHV1-3 →	+2.916	+0.491	<.001	<.001	3	7
BRCA	IGLV3-1 →	+3.257	+0.757	<.001	<.001	3	7
BRCA	IGHG1 →	+2.688	+0.585	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,749 associations by consensus.

Exploration

IGHV2-5 survival (RNA) · tumor vs normal (RNA) · all IGHV2-5 data types