Across TCGA patient cohorts, IGHV2-26 protein abundance is significantly associated with the RNA expression of many other genes, with 8,869 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHV2-26-associated genes across cancer lineages are TPTE2, IGHV1-24, and IGHV1-69D. Each is linked with IGHV2-26 in more than 3 cancer types. Because this analysis shows association rather than direction, both IGHV2-26-to-partner and partner-to-IGHV2-26 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV2-26→partner) and Y-score (partner→IGHV2-26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TPTE2 →	+0.589	+0.489	.008	<.001	3	4
COAD	IGHV1-24 →	+2.161	+0.666	.006	.002	3	4
UCEC	IGHV1-69D →	+2.614	+0.502	.001	.003	3	4
GBM	TRIM45 →	-0.520	-0.631	<.001	.001	3	4
OV	APBB1IP →	+0.749	+0.696	.006	.008	3	4
LSCC	KIF22 →	-0.557	-0.627	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,869 associations by consensus.

Exploration

IGHV2-26 survival (RNA) · tumor vs normal (RNA) · all IGHV2-26 data types