IGHV1OR16-3

Across TCGA pan-cancer cohorts, IGHV1OR16-3 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated IGHV1OR16-3 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV1OR16-3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGHV1OR16-3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and SKCM are the cancer types where IGHV1OR16-3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.768	0.605	<.001	137	view →
UCEC	DFS	Tertile	III,IV	0.862	0.501	.002	72	view →
SKCM	DFS	Median	All	0.265	0.169	<.001	64	view →
LUAD	DFS	Tertile	II,III,IV	0.799	0.489	.001	52	view →
LGG	OS	Tertile	All	0.180	0.451	<.001	48	view →
LIHC	DFS	Tertile	II,III,IV	0.625	0.386	.006	48	view →
KICH	OS	Tertile	All	0.155	0.926	<.001	45	view →
BRCA	DFS	Median	All	0.626	0.469	<.001	40	view →
THYM	DFS	Tertile	III,IV	0.317	0.913	<.001	27	view →
STAD	OS	Tertile	III,IV	0.337	0.612	.018	25	view →
DLBC	DFS	Quartile	III,IV	0.074	0.984	.008	18	view →
GBM	OS	Tertile	All	0.189	0.419	.004	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

IGHV1OR16-3–HNSC (OS)

Open the HNSC breakdown →