IGHV1OR16-1

Across TCGA pan-cancer cohorts, IGHV1OR16-1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IGHV1OR16-1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV1OR16-1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV1OR16-1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGHV1OR16-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.780	0.641	<.001	126	view →
SKCM	OS	Median	All	0.423	0.290	.001	80	view →
BRCA	DFS	Median	All	0.969	0.928	<.001	69	view →
UVM	DFS	Tertile	All	0.335	0.779	.004	54	view →
LGG	OS	Tertile	All	0.691	0.897	<.001	33	view →
DLBC	DFS	Tertile	All	0.391	0.906	.005	27	view →
GBM	OS	Tertile	All	0.123	0.427	.001	27	view →
LIHC	OS	Tertile	II,III,IV	0.877	0.675	.014	24	view →
BLCA	OS	Median	IV	0.595	0.267	.006	22	view →
LUAD	DFS	Tertile	All	0.770	0.617	.010	21	view →
KICH	OS	Tertile	II,III,IV	0.155	0.880	<.001	18	view →
CHOL	DFS	Tertile	III,IV	1.000	0.182	.034	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

IGHV1OR16-1–HNSC (DFS)

Open the HNSC breakdown →