IGHV1OR15-6

Across TCGA pan-cancer cohorts, IGHV1OR15-6 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated IGHV1OR15-6 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV1OR15-6 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV1OR15-6 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LIHC show a favorable association.

HNSC, LIHC, and GBM are the cancer types where IGHV1OR15-6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.795	0.665	.002	87	view →
LIHC	DFS	Tertile	III,IV	0.762	0.133	.003	60	view →
GBM	DFS	Tertile	All	0.035	0.260	<.001	36	view →
TGCT	OS	Tertile	III,IV	0.003	1.000	<.001	36	view →
SKCM	DFS	Quartile	III,IV	0.729	0.572	.015	28	view →
KIRP	DFS	Tertile	III,IV	0.180	0.655	<.001	27	view →
UVM	OS	Tertile	All	0.292	0.674	.035	18	view →
BRCA	DFS	Quartile	II,III,IV	0.974	0.932	.022	15	view →
BLCA	DFS	Tertile	All	0.646	0.433	.041	12	view →
THCA	OS	Tertile	IV	0.813	1.000	.039	9	view →
LGG	OS	Tertile	All	0.718	0.910	.020	9	view →
STAD	DFS	Median	IV	0.565	0.158	.012	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

IGHV1OR15-6–HNSC (DFS)

Open the HNSC breakdown →