IGHV1OR15-2

Across TCGA pan-cancer cohorts, IGHV1OR15-2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated IGHV1OR15-2 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV1OR15-2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGHV1OR15-2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGHV1OR15-2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.764	0.606	<.001	138	view →
SKCM	OS	Median	All	0.410	0.280	<.001	90	view →
BRCA	OS	Median	All	0.977	0.947	<.001	80	view →
DLBC	DFS	Tertile	All	0.465	1.000	.007	46	view →
LIHC	DFS	Median	III,IV	0.630	0.236	.001	30	view →
ACC	DFS	Tertile	III,IV	0.010	0.364	<.001	27	view →
UCEC	OS	Tertile	III,IV	0.784	0.454	.007	24	view →
STAD	DFS	Median	All	0.554	0.694	.006	18	view →
KIRC	DFS	Tertile	All	0.523	0.707	.032	10	view →
COAD	OS	Quartile	III,IV	0.888	0.559	.015	10	view →
GBM	DFS	Tertile	All	0.138	0.308	.033	9	view →
LGG	DFS	Tertile	All	0.652	0.843	.004	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

IGHV1OR15-2–HNSC (OS)

Open the HNSC breakdown →