Across TCGA pan-cancer cohorts, IGHV1-46 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IGHV1-46 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher IGHV1-46 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV1-46 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where IGHV1-46 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.882	0.522	.003	27	view →
LUAD	DFS	Quartile	II,III,IV	1.000	0.220	.014	13	view →
HNSC	DFS	Tertile	All	0.917	1.000	.010	8	view →
LSCC	DFS	Quartile	II,III,IV	0.433	0.927	.004	4	view →
UCEC	DFS	Median	All	0.947	1.000	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: IGHV1-46 tumor-vs-normal RNA expression · all IGHV1-46 data types