Across TCGA pan-cancer cohorts, IGHV1-45 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IGHV1-45 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IGHV1-45 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHV1-45 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

UCEC, LUAD, and HNSC are the cancer types where IGHV1-45 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.799	0.983	.013	14	view →
LUAD	OS	Quartile	All	0.879	1.000	.009	10	view →
HNSC	DFS	Quartile	III,IV	1.000	0.848	.030	3	view →
GBM	OS	Median	All	0.762	0.932	.036	1	view →
LSCC	DFS	Median	II,III,IV	0.867	0.963	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: IGHV1-45 tumor-vs-normal RNA expression · all IGHV1-45 data types