Across TCGA patient cohorts, IGHV1-45 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,180 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHV1-45-associated proteins across cancer lineages are MZB1, IL16, and CD38. Each is linked with IGHV1-45 in more than 7 cancer types. Because this analysis shows association rather than direction, both IGHV1-45-to-partner and partner-to-IGHV1-45 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV1-45→partner) and Y-score (partner→IGHV1-45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MZB1 →	+1.040	+0.574	<.001	<.001	3	8
OV	IL16 →	+0.506	+0.787	<.001	<.001	3	8
HNSC	CD38 →	+0.788	+1.171	<.001	<.001	3	8
UCEC	HCLS1 →	+0.528	+1.272	<.001	.001	3	7
OV	DOCK2 →	+0.451	+0.719	<.001	<.001	3	7
HNSC	TXNDC5 →	+0.556	+1.070	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,180 associations by consensus.

Exploration

IGHV1-45 survival (RNA) · tumor vs normal (RNA) · all IGHV1-45 data types