Across TCGA patient cohorts, IGHV1-45 protein abundance is significantly associated with the RNA expression of many other genes, with 8,395 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHV1-45-associated genes across cancer lineages are IGHV1-69D, IGHV3OR16-13, and IRF4. Each is linked with IGHV1-45 in more than 4 cancer types. Because this analysis shows association rather than direction, both IGHV1-45-to-partner and partner-to-IGHV1-45 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV1-45→partner) and Y-score (partner→IGHV1-45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	IGHV1-69D →	+2.248	+1.109	<.001	.001	3	5
UCEC	IGHV3OR16-13 →	+1.494	+0.803	.006	.009	3	4
LUAD	IRF4 →	+1.015	+0.906	<.001	<.001	3	4
HNSC	MAD2L1BP →	-0.510	-0.616	.003	.003	3	3
HNSC	ETFA →	-0.386	-0.616	.001	.003	3	3
HNSC	EXOSC10 →	-0.355	-0.856	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,395 associations by consensus.

Exploration

IGHV1-45 survival (RNA) · tumor vs normal (RNA) · all IGHV1-45 data types