Across TCGA patient cohorts, IGHV1-45 mutation is significantly associated with the RNA expression of many other genes, with 279 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGHV1-45-associated genes across cancer lineages are RNASEK-C17orf49, DAPK3, and ARRDC1-AS1. Each is linked with IGHV1-45 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV1-45-to-partner and partner-to-IGHV1-45 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV1-45→partner) and Y-score (partner→IGHV1-45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNASEK-C17orf49 →	+0.408	+3.332	<.001	.005	3	2
UCEC	DAPK3 →	+0.643	+3.354	.001	.005	3	2
SKCM	ARRDC1-AS1 →	+0.518	+3.651	<.001	.001	3	2
SKCM	PIN1 →	+0.468	+2.604	.001	.005	3	2
SKCM	DPM2 →	+0.450	+3.341	.004	.005	3	2
SKCM	MRPL54 →	+0.479	+2.706	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 279 associations by consensus.

Exploration

IGHV1-45 survival (RNA) · tumor vs normal (RNA) · all IGHV1-45 data types