Across TCGA patient cohorts, IGHV1-45 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHV1-45-associated genes across cancer lineages are 14-3-3_beta, JNK_pT183_Y185, and JNK2. Each is linked with IGHV1-45 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV1-45-to-partner and partner-to-IGHV1-45 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV1-45→partner) and Y-score (partner→IGHV1-45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.164	-2.979	.004	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.247	-3.000	.011	.036	3	1
UCEC	JNK2 →	+0.284	+2.817	.013	.036	3	1
UCEC	Notch1 →	+0.292	+2.820	<.001	.035	3	1
UCEC	AR →	-0.447	-3.000	.038	.037	3	1
UCEC	Cyclin-E2 →	+0.209	+2.817	.032	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Exploration

IGHV1-45 survival (RNA) · tumor vs normal (RNA) · all IGHV1-45 data types