Across TCGA pan-cancer cohorts, IGHV1-3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IGHV1-3 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IGHV1-3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated IGHV1-3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

UCEC, CCRCC, and LUAD are the cancer types where IGHV1-3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	All	0.877	1.000	.024	28	view →
CCRCC	OS	Median	All	0.924	0.741	.007	26	view →
LUAD	OS	Median	II,III,IV	0.862	1.000	.004	17	view →
LSCC	DFS	Median	II,III,IV	0.547	0.842	.012	10	view →
PDAC	OS	Tertile	All	0.504	0.262	.020	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: IGHV1-3 tumor-vs-normal RNA expression · all IGHV1-3 data types