Across TCGA patient cohorts, IGHV1-3 RNA expression is significantly associated with the mutation status of many other genes, with 8,277 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHV1-3-associated genes across cancer lineages are PCDHGB3, LRRC7, and CNTN5. Each is linked with IGHV1-3 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGHV1-3-to-partner and partner-to-IGHV1-3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV1-3→partner) and Y-score (partner→IGHV1-3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCDHGB3 →	-3.700	-1.012	.001	.003	3	3
COAD	LRRC7 →	+3.999	+1.088	<.001	<.001	3	3
UCEC	CNTN5 →	+2.697	+0.742	<.001	.005	3	3
UCEC	GUCY1A2 →	+2.233	+0.885	<.001	.003	3	3
UCEC	NAV3 →	+1.537	+0.786	<.001	<.001	3	3
SKCM	SLC29A4 →	+3.591	+1.733	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,277 associations by consensus.

Exploration

IGHV1-3 survival (RNA) · tumor vs normal (RNA) · all IGHV1-3 data types