IGHMBP2

Across TCGA patient cohorts, IGHMBP2 mutation is significantly associated with the RNA expression of many other genes, with 1,289 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHMBP2-associated genes across cancer lineages are NDUFA6, DHDDS, and CKS2. Each is linked with IGHMBP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGHMBP2-to-partner and partner-to-IGHMBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFA6 grouped by IGHMBP2-low versus IGHMBP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHMBP2→partner) and Y-score (partner→IGHMBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFA6 →	+0.437	+3.343	<.001	<.001	3	3
UCEC	DHDDS →	+0.303	+1.617	<.001	.004	3	3
UCEC	CKS2 →	+0.434	+1.950	.005	.002	3	3
UCEC	GCH1 →	+0.690	+2.082	<.001	<.001	3	3
UCEC	UBQLN1 →	+0.390	+2.032	.002	.001	3	3
STAD	MRPL16 →	+0.487	+3.270	.008	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,289 associations by consensus.

NDUFA6 by IGHMBP2 expression — UCEC

Explore this box plot interactively →