IGHMBP2

Across TCGA cell cohorts, IGHMBP2 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IGHMBP2-associated genes across cancer lineages are TFDP3, AWAT2, and TMIGD1. Each is linked with IGHMBP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHMBP2-to-partner and partner-to-IGHMBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFDP3 grouped by IGHMBP2-low versus IGHMBP2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHMBP2→partner) and Y-score (partner→IGHMBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TFDP3 →	+0.019	+4.857	<.001	<.001	3	2
BLOOD_Leukemia	AWAT2 →	+0.015	+4.705	<.001	.003	3	2
CNS	TMIGD1 →	+0.028	+4.169	<.001	.008	3	2
OESOPHAGUS	ARSF →	+0.023	+4.392	.003	.003	3	1
BLOOD_Lymphoma	ACTL9 →	+0.199	+4.867	<.001	.009	3	1
SKIN	MYH8 →	+0.046	+3.716	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

TFDP3 by IGHMBP2 expression — OESOPHAGUS

Explore this box plot interactively →