Across TCGA patient cohorts, IGHM RNA expression is significantly associated with the protein abundance of many other proteins, with 14,400 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGHM-associated proteins across cancer lineages are MZB1, SEPTIN1, and WAS. Each is linked with IGHM in more than 9 cancer types. Because this analysis shows association rather than direction, both IGHM-to-partner and partner-to-IGHM results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHM→partner) and Y-score (partner→IGHM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MZB1 →	+1.739	+3.661	<.001	<.001	3	10
GBM	SEPTIN1 →	+1.197	+2.137	<.001	<.001	3	10
GBM	WAS →	+0.569	+1.753	<.001	<.001	3	10
HNSC	CD48 →	+0.949	+3.043	<.001	<.001	3	10
BRCA	CORO1A →	+0.647	+2.974	<.001	<.001	3	10
UCEC	DOCK10 →	+0.568	+2.700	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,400 associations by consensus.

Exploration

IGHM survival (RNA) · tumor vs normal (RNA) · all IGHM data types