Across TCGA patient cohorts, IGHM protein abundance is significantly associated with the RNA expression of many other genes, with 8,283 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGHM-associated genes across cancer lineages are IGKJ5, IGLV2-11, and IGHJ6. Each is linked with IGHM in more than 6 cancer types. Because this analysis shows association rather than direction, both IGHM-to-partner and partner-to-IGHM results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHM→partner) and Y-score (partner→IGHM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IGKJ5 →	+2.893	+0.784	<.001	<.001	3	7
OV	IGLV2-11 →	+1.843	+0.624	.003	.003	3	7
OV	IGHJ6 →	+3.574	+0.915	<.001	.001	3	7
BRCA	IGHV3-23 →	+3.186	+0.870	<.001	<.001	3	7
OV	IGKV1-16 →	+3.363	+0.954	<.001	.002	3	7
BRCA	IGLV2-8 →	+2.787	+0.874	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,283 associations by consensus.

Exploration

IGHM survival (RNA) · tumor vs normal (RNA) · all IGHM data types