Across TCGA patient cohorts, IGHM protein abundance is significantly associated with the protein abundance of many other proteins, with 13,495 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHM-associated proteins across cancer lineages are IGHG2, IGHV3-49, and IGHV3-7. Each is linked with IGHM in more than 9 cancer types. Because this analysis shows association rather than direction, both IGHM-to-partner and partner-to-IGHM results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHM→partner) and Y-score (partner→IGHM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IGHG2 →	+0.798	+0.803	<.001	.002	3	10
OV	IGHV3-49 →	+1.490	+1.176	<.001	<.001	3	10
GBM	IGHV3-7 →	+0.874	+0.829	<.001	<.001	3	10
GBM	IGHV3-72 →	+0.727	+0.894	<.001	<.001	3	10
PDAC	IGHV3OR16-12 →	+1.130	+0.868	<.001	<.001	3	10
OV	IGKC →	+0.943	+1.333	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,495 associations by consensus.

Exploration

IGHM survival (RNA) · tumor vs normal (RNA) · all IGHM data types