Across TCGA patient cohorts, IGHM mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHM-associated genes across cancer lineages are STAT3_pY705, Caspase-7-cleavedD198, and TFRC. Each is linked with IGHM in more than 3 cancer types. Because this analysis shows association rather than direction, both IGHM-to-partner and partner-to-IGHM results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHM→partner) and Y-score (partner→IGHM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	STAT3_pY705 →	-0.210	-1.644	.013	.018	3	4
STAD	Caspase-7-cleavedD198 →	+0.846	+3.000	.027	.036	3	3
UCEC	TFRC →	+0.385	+3.459	.021	.005	3	3
UCEC	ATM →	-0.354	-1.353	.013	.015	3	3
LUAD	4E-BP1_pT70 →	+0.243	+2.824	.028	.036	3	2
STAD	Smad1 →	+0.324	+3.000	<.001	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Exploration

IGHM survival (RNA) · tumor vs normal (RNA) · all IGHM data types