Across TCGA patient cohorts, IGHJ2 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGHJ2-associated genes across cancer lineages are MIR6752, MTND1P33, and OR7E53P. Each is linked with IGHJ2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHJ2-to-partner and partner-to-IGHJ2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHJ2→partner) and Y-score (partner→IGHJ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR6752 →	+0.607	+6.199	<.001	.001	3	1
SKCM	MTND1P33 →	+0.065	+6.624	<.001	.001	3	1
SKCM	OR7E53P →	+0.128	+5.292	<.001	.006	3	1
SKCM	TUBBP11 →	+0.199	+4.979	.001	.009	3	1
SKCM	RN7SL446P →	+0.201	+5.513	<.001	.004	3	1
SKCM	C5orf66-AS2 →	+0.028	+5.362	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

IGHJ2 survival (RNA) · tumor vs normal (RNA) · all IGHJ2 data types