IGHGP

Across TCGA pan-cancer cohorts, IGHGP RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated IGHGP data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHGP RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHGP expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGHGP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.752	0.638	<.001	144	view →
SKCM	OS	Median	II,III,IV	0.405	0.227	<.001	105	view →
BRCA	DFS	Quartile	All	0.700	0.429	<.001	58	view →
OV	DFS	Tertile	All	0.193	0.118	.007	42	view →
KIRC	DFS	Median	All	0.513	0.734	<.001	38	view →
CESC	OS	Tertile	All	0.902	0.732	<.001	38	view →
UVM	DFS	Median	All	0.562	0.884	<.001	37	view →
SARC	OS	Tertile	All	0.639	0.409	<.001	35	view →
LUAD	DFS	Median	II,III,IV	0.685	0.428	.001	31	view →
COAD	OS	Quartile	III,IV	0.843	0.515	.011	24	view →
READ	DFS	Median	III,IV	0.704	0.417	.004	24	view →
GBM	OS	Tertile	All	0.267	0.556	.001	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

IGHGP–HNSC (DFS)

Open the HNSC breakdown →