Across TCGA pan-cancer cohorts, IGHG4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IGHG4 data layer compared with 23 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHG4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHG4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, PDAC, and COAD are the cancer types where IGHG4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.978	0.177	.010	38	view →
PDAC	DFS	Median	II,III,IV	0.288	0.478	.001	32	view →
COAD	DFS	Median	III,IV	0.838	1.000	.037	12	view →
UCEC	DFS	Tertile	All	0.861	1.000	.002	12	view →
LSCC	DFS	Quartile	All	1.000	0.356	.004	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: IGHG4 tumor-vs-normal RNA expression · all IGHG4 data types