Across TCGA patient cohorts, IGHG4 RNA expression is significantly associated with the mutation status of many other genes, with 11,211 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHG4-associated genes across cancer lineages are TTN, SLC8A3, and NEB. Each is linked with IGHG4 in more than 3 cancer types. Because this analysis shows association rather than direction, both IGHG4-to-partner and partner-to-IGHG4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHG4→partner) and Y-score (partner→IGHG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	TTN →	-1.182	-1.110	<.001	<.001	3	4
LUAD	SLC8A3 →	-3.459	-1.198	.005	.004	3	3
UCEC	NEB →	+1.044	+1.387	<.001	<.001	3	3
UCEC	HGF →	+2.321	+2.282	<.001	<.001	3	3
COAD	LTBP2 →	+2.827	+2.052	.001	<.001	3	2
COAD	UBE3B →	+3.342	+1.974	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,211 associations by consensus.

Exploration

IGHG4 survival (RNA) · tumor vs normal (RNA) · all IGHG4 data types