Across TCGA patient cohorts, IGHG4 protein abundance is significantly associated with the RNA expression of many other genes, with 12,081 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGHG4-associated genes across cancer lineages are IGHE, IGHV1-67, and CYTH4. Each is linked with IGHG4 in more than 4 cancer types. Because this analysis shows association rather than direction, both IGHG4-to-partner and partner-to-IGHG4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHG4→partner) and Y-score (partner→IGHG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IGHE →	+1.230	+0.992	<.001	<.001	3	5
LUAD	IGHV1-67 →	+1.089	+0.672	<.001	.001	3	5
HNSC	CYTH4 →	+0.790	+0.562	<.001	.001	3	4
HNSC	ASF1B →	-0.820	-0.556	.002	.003	3	4
GBM	TNFSF8 →	+0.838	+0.633	<.001	<.001	3	4
LSCC	P2RX1 →	+0.820	+0.737	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,081 associations by consensus.

Exploration

IGHG4 survival (RNA) · tumor vs normal (RNA) · all IGHG4 data types