Across TCGA patient cohorts, IGHG4 mutation is significantly associated with the RNA expression of many other genes, with 755 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHG4-associated genes across cancer lineages are GINS3, DBR1, and OR6K2. Each is linked with IGHG4 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGHG4-to-partner and partner-to-IGHG4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHG4→partner) and Y-score (partner→IGHG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GINS3 →	+0.562	+2.828	.001	.001	3	3
UCEC	DBR1 →	+0.500	+3.499	.004	.002	3	3
BLCA	OR6K2 →	+0.053	+6.018	<.001	.002	3	2
BLCA	RNA5SP84 →	+0.421	+7.307	<.001	<.001	3	2
SKCM	CACTIN →	+0.439	+3.529	.005	.002	3	2
SKCM	KXD1 →	+0.342	+3.504	.008	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 755 associations by consensus.

Exploration

IGHG4 survival (RNA) · tumor vs normal (RNA) · all IGHG4 data types