Across TCGA pan-cancer cohorts, IGHG3 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IGHG3 data layer compared with 21 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher IGHG3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IGHG3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

READ, LGG, and UCEC are the cancer types where IGHG3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	All	0.166	0.830	<.001	12	view →
LGG	DFS	Median	All	0.161	0.753	<.001	6	view →
UCEC	DFS	Median	All	1.000	0.630	.032	6	view →
SKCM	OS	Median	III,IV	0.967	0.794	.030	4	view →
SARC	DFS	Median	All	0.096	0.591	.006	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: IGHG3 tumor-vs-normal RNA expression · all IGHG3 data types