Across TCGA patient cohorts, IGHG3 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGHG3-associated genes across cancer lineages are Caspase-7-cleavedD198, c-Met_pY1235, and GATA6. Each is linked with IGHG3 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGHG3-to-partner and partner-to-IGHG3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHG3→partner) and Y-score (partner→IGHG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.725	+3.169	.008	.018	3	3
UCEC	c-Met_pY1235 →	+0.073	+2.584	.036	.011	3	3
SKCM	GATA6 →	-0.179	-2.970	.020	.030	3	2
UCEC	JNK2 →	+0.209	+2.179	.023	.034	3	1
UCEC	E-Cadherin →	+0.513	+2.179	.023	.034	3	1
SKCM	NF-kB-p65_pS536 →	+0.330	+1.485	.007	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

IGHG3 survival (RNA) · tumor vs normal (RNA) · all IGHG3 data types