Across TCGA patient cohorts, IGHG2 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,326 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGHG2-associated proteins across cancer lineages are MZB1, ARHGAP25, and RCSD1. Each is linked with IGHG2 in more than 9 cancer types. Because this analysis shows association rather than direction, both IGHG2-to-partner and partner-to-IGHG2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHG2→partner) and Y-score (partner→IGHG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MZB1 →	+1.641	+3.473	<.001	<.001	3	10
OV	ARHGAP25 →	+1.122	+3.405	.002	.003	3	10
BRCA	RCSD1 →	+0.474	+2.003	<.001	<.001	3	10
OV	WIPF1 →	+0.462	+2.798	<.001	<.001	3	10
GBM	FYB1 →	+0.761	+2.103	<.001	<.001	3	10
GBM	HCLS1 →	+0.690	+2.113	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,326 associations by consensus.

Exploration

IGHG2 survival (RNA) · tumor vs normal (RNA) · all IGHG2 data types