Across TCGA patient cohorts, IGHG2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHG2-associated genes across cancer lineages are MEK1, mTOR_pS2448, and PCNA. Each is linked with IGHG2 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGHG2-to-partner and partner-to-IGHG2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHG2→partner) and Y-score (partner→IGHG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.446	+3.321	.011	.010	3	2
UCEC	mTOR_pS2448 →	-0.191	-2.980	.007	.036	3	2
UCEC	PCNA →	+0.331	+3.169	.001	.019	2	3
UCEC	STAT3_pY705 →	-0.620	-3.584	<.001	.002	3	2
UCEC	ASNS →	+0.754	+2.459	<.001	.020	3	2
UCEC	B-Raf →	+0.348	+3.189	.045	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

IGHG2 survival (RNA) · tumor vs normal (RNA) · all IGHG2 data types