Across TCGA patient cohorts, IGHG1 mutation is significantly associated with the RNA expression of many other genes, with 6,529 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHG1-associated genes across cancer lineages are UBXN8, EPHX3, and TMEM269. Each is linked with IGHG1 in more than 4 cancer types. Because this analysis shows association rather than direction, both IGHG1-to-partner and partner-to-IGHG1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHG1→partner) and Y-score (partner→IGHG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UBXN8 →	+0.288	+2.305	.004	<.001	3	5
ESCA	EPHX3 →	-2.447	-3.294	<.001	.008	2	5
LUAD	TMEM269 →	+0.196	+2.861	<.001	<.001	3	4
SKCM	ITPK1 →	+0.253	+0.976	.008	.003	3	4
UCEC	MDC1 →	+0.462	+2.002	<.001	<.001	3	4
UCEC	TMEM251 →	+0.357	+1.644	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,529 associations by consensus.

Exploration

IGHG1 survival (RNA) · tumor vs normal (RNA) · all IGHG1 data types