IGHEP2

Across TCGA pan-cancer cohorts, IGHEP2 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of IGHEP2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where IGHEP2 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHEP2 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and UCEC are the cancer types where IGHEP2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHEP2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−0.137	<.001	8	view →
KICH	All	All	−0.081	.008	4	view →
UCEC	All	IV	+0.120	.026	2	view →
LIHC	All	II,III,IV	+0.071	.036	2	view →
COAD	Female	All	−0.055	.027	2	view →
READ	All	All	−0.090	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

IGHEP2–THCA

Open the THCA breakdown →