Across TCGA patient cohorts, IGHE protein abundance is significantly associated with the RNA expression of many other genes, with 1,842 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible IGHE-associated genes across cancer lineages are IRF5, MRPL18, and PATJ. Each is linked with IGHE in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHE-to-partner and partner-to-IGHE results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHE→partner) and Y-score (partner→IGHE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IRF5 →	+0.513	+0.891	.002	.001	3	2
HNSC	MRPL18 →	-0.674	-0.420	.006	.002	3	2
HNSC	PATJ →	-0.660	-0.631	<.001	.001	3	2
HNSC	FBXO22 →	-0.723	-0.594	.002	<.001	3	2
HNSC	SETD4 →	-0.690	-0.628	.003	<.001	3	2
PDAC	SUSD2 →	+1.029	+0.806	.006	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,842 associations by consensus.

Exploration

IGHE survival (RNA) · tumor vs normal (RNA) · all IGHE data types