Across TCGA patient cohorts, IGHE mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHE-associated genes across cancer lineages are ATM, mTOR_pS2448, and Notch1. Each is linked with IGHE in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHE-to-partner and partner-to-IGHE results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHE→partner) and Y-score (partner→IGHE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ATM →	-0.461	-3.169	.014	.018	3	2
UCEC	mTOR_pS2448 →	-0.157	-2.000	.019	.032	3	2
UCEC	Notch1 →	+0.230	+2.335	<.001	.018	3	2
SKCM	IRS1 →	+0.294	+3.321	<.001	.009	3	1
SKCM	AMPK_alpha →	+0.241	+3.169	<.001	.018	3	1
UCEC	HSP70 →	-0.438	-2.700	.015	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

IGHE survival (RNA) · tumor vs normal (RNA) · all IGHE data types