Across TCGA patient cohorts, IGHD6-25 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,956 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHD6-25-associated proteins across cancer lineages are MZB1, ARHGAP25, and CD38. Each is linked with IGHD6-25 in more than 6 cancer types. Because this analysis shows association rather than direction, both IGHD6-25-to-partner and partner-to-IGHD6-25 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHD6-25→partner) and Y-score (partner→IGHD6-25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MZB1 →	+1.348	+1.059	<.001	<.001	3	7
UCEC	ARHGAP25 →	+0.546	+1.409	<.001	<.001	3	7
BRCA	CD38 →	+1.135	+1.763	<.001	<.001	3	7
UCEC	DOK2 →	+0.577	+1.381	<.001	<.001	3	7
LSCC	EVI2B_S268 →	+0.762	+1.597	<.001	<.001	3	7
OV	IL16 →	+0.570	+1.059	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,956 associations by consensus.

Exploration

IGHD6-25 survival (RNA) · tumor vs normal (RNA) · all IGHD6-25 data types