Across TCGA pan-cancer cohorts, IGHD5-24 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of IGHD5-24’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where IGHD5-24 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGHD5-24 is over-expressed in tumor.

LUSC, LUAD, and STAD are the cancer types where IGHD5-24 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHD5-24 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	+0.218	.011	3	view →
LUAD	All	All	+0.221	.031	2	view →
STAD	Female	III,IV	+1.710	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: IGHD5-24 RNA expression & survival · all IGHD5-24 data types